Charge transfer through DNA depends upon DNA stranded ness i.e., whether the DNA is single stranded or double stranded. Since, it has been reported by scientist that in perfect double stranded DNA the charge transfer is extremely large as compared to single stranded DNA. This is the reason given by scientists on why a single base pair mismatch can be so easily detected if the principle of charge transfer through DNA is used for detection.
Also, intercalators can be used to enhance the rate of charge transfer which can undergo reduction-oxidation reaction at much more lower potential than guanine. Hence, this help in increasing the amount of charge transfer through DNA which increases the sensitivity of DNA to charge transfer.
Intercalator can be used in two ways:
- Only one intercalator can be used, which act as donor for the charge
- Even intercalators can be used in combination, such that one acts as charge donor while the other acts as the charge acceptor
So, now I think all readers must have got some idea about the charge transfer through DNA. But since this topic is very controversial so I would like to suggest that don't jump to conclusions just by reading this topic. But, use this topic in helping you to develop exact concept behind charge transfer through DNA. Since, this is just my viewpoint and not an experimentally proved fact.
